胆道癌的多基因突变特征与手术切除患者的复

Abstract

Theaimofthepresentstudywastoinvestigatetherelationshipbetweenthemutationalgeneprofileandrecurrenceinbiliarytractcancers(BTC).AtotalofspecimensofpatientswithBTC,whounderwentcurativesurgeryinasingletertiaryHPBsurgeryreferralcenterfromto,wereassessedformutationalstatusin52cancer-relatedgenes.ConsideringthedifferenttypesofBTC,the5-yearrecurrence-freesurvival(RFS)ratewas16.7%(medianRFS7months)ingallbladdercancer,42.9%(medianRFS26.4months)inintrahepaticcholangiocarcinoma,and19.7%(medianRFS16.5months)inperihilarcholangiocarcinoma,p=0..Atthemultivariateanalysisincludingclinical,pathological,andmolecularfeatures,thefactorsindependentlyrelatedtoRFSwereradicalityofsurgery(OR2.,CI1.–3.,p=0.),LNstatus(OR1.,CI1.–3.,p=0.),mutationalstatusofARID1A(OR2.,CI1.–5.,p=0.),andTP53(OR2.,CI4.–5.,p=0.).ARID1Amutationwasassociatedwithalocalandsystemicrecurrenceinthe43%and29%ofcases,respectively;andTP53mutationwasassociatedwithalocalandsystemicrecurrenceinthe29%and41%ofcases.Moreover,TP53wasmost